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Coadministration of the HIV protease inhibitor ritonavir, which is ahighly potent P450 inhibitor, at steady state (500 mg bid) with sildenafil (100 mg single dose) resulted in a 300 % (4-fold) increase in sildenafil Cmax and a 1,000 % (11-fold) increase in sildenafil plasma AUC. viagra as alprostadil sterile powder or alfadex. Combinations of.


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